Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 8/20 | 0.70 |
| ▸ | EGLN1 | Q9GZT9 | 4/20 | 0.38 |
| ▸ | ATR | Q13535 | 2/20 | 0.36 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | MERTK | Q12866 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.35 |
| ▸ | SYK | P43405 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29608776 | 1.00 | MAP4K1 (0.70) | MAP4K1EGLN1ATRCYP11B2AXL | |
| SCHEMBL22858709 | 0.91 | MAP4K1 (0.75) | MAP4K1MAPK1 | |
| SCHEMBL22858897 | 0.88 | MAP4K1 (0.63) | MAP4K1EGLN1ATRCYP11B2AXL | |
| SCHEMBL22858747 | 0.88 | MAP4K1 (0.70) | MAP4K1EGLN1MAPK1 | |
| SCHEMBL29607897 | 0.88 | MAP4K1 (0.70) | MAP4K1EGLN1MAPK1 | |
| SCHEMBL22858685 | 0.88 | MAP4K1 (0.86) | MAP4K1AXLMERTKMAPK1 | |
| SCHEMBL29608972 | 0.88 | MAP4K1 (0.86) | MAP4K1AXLMERTKMAPK1 | |
| SCHEMBL22858869 | 0.86 | MAP4K1 (0.81) | MAP4K1MAPK1 | |
| SCHEMBL22858774 | 0.86 | MAP4K1 (0.72) | MAP4K1MAPK1 | |
| SCHEMBL22858708 | 0.86 | MAP4K1 (0.81) | MAP4K1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115073474-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-20 | — | — | CN | disclosed |
| CN-115028639-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-09-09 | — | — | CN | disclosed |
| CN-114096536-A | Pyrrolo [2,3-b ] pyrazines as HPK1 inhibitors and uses thereof | 百济神州有限公司 | 2022-02-25 | — | — | CN | disclosed |
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |