Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.80 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.35 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29609110 | 1.00 | MAP4K1 (0.80) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL22858795 | 0.94 | MAP4K1 (0.80) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL29608148 | 0.94 | MAP4K1 (0.80) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL24954370 | 0.94 | MAP4K1 (0.72) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL22859048 | 0.94 | MAP4K1 (0.78) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| Hydrochloric Acid SCHEMBL30215931 | 0.94 | MAP4K1 (0.71) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL22858921 | 0.93 | MAP4K1 (0.69) | MAP4K1TNIKPIK3CGMAPK1S1PR1 | |
| SCHEMBL29608963 | 0.93 | MAP4K1 (0.69) | MAP4K1TNIKPIK3CGMAPK1S1PR1 | |
| SCHEMBL22858716 | 0.93 | MAP4K1 (0.77) | MAP4K1TNIKCAMKK2JAK2JAK1 | |
| SCHEMBL29609233 | 0.93 | MAP4K1 (0.77) | MAP4K1TNIKCAMKK2JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021000925-A1 | PYRROLO [2, 3-b] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-07 | — | — | WO | disclosed |