Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 19/20 | 1.00 |
| ▸ | BRD2 | P25440 | 2/20 | 0.73 |
| ▸ | BRD3 | Q15059 | 2/20 | 0.73 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.73 |
| ▸ | TRIM24 | O15164 | 1/20 | 0.73 |
| ▸ | BRD1 | O95696 | 1/20 | 0.73 |
| ▸ | TAF1 | P21675 | 1/20 | 0.73 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.73 |
| ▸ | EP300 | Q09472 | 1/20 | 0.73 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.73 |
| ▸ | TAF1L | Q8IZX4 | 1/20 | 0.73 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.73 |
| ▸ | CECR2 | Q9BXF3 | 1/20 | 0.73 |
| ▸ | BRD8 | Q9H0E9 | 1/20 | 0.73 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.73 |
| ▸ | BAZ2A | Q9UIF9 | 1/20 | 0.73 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29777077 | 1.00 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL29777088 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL22863270 | 0.92 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL22863380 | 0.85 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL29777081 | 0.85 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL26934742 | 0.85 | BRD4 (0.73) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL29777120 | 0.84 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL22863358 | 0.84 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL22863266 | 0.84 | BRD4 (1.00) | BRD4BRD2BRD3BRDTTRIM24 | |
| SCHEMBL22863427 | 0.84 | BRD4 (0.76) | BRD4BRD2BRD3BRDTTRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11840533-B2 | Pyridinone-based epigenetic modifiers and uses thereof | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-12-12 | — | — | US | disclosed |
| US-11840533-B2 | Pyridinone-based epigenetic modifiers and uses thereof | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2023-12-12 | — | — | US | disclosed |
| US-11332466-B2 | Pyridinone-based epigenetic modifiers and uses thereof | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2022-05-17 | — | — | US | disclosed |
| US-20210002272-A1 | PYRIDINONE-BASED EPIGENETIC MODIFIERS AND USES THEREOF | UNIV ILLINOIS (US) | 2021-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210002272-A1 | PYRIDINONE-BASED EPIGENETIC MODIFIERS AND USES THEREOF | BRD1, BRD2, BRD3 | BRD4 5/4885BRD2 2/4885BRD3 3/4885 |
| US-11332466-B2 | Pyridinone-based epigenetic modifiers and uses thereof | BRD1, BRD2, BRD3 | BRD4 5/4885BRD2 2/4885BRD3 3/4885 |
| US-11840533-B2 | Pyridinone-based epigenetic modifiers and uses thereof | BRD1, BRD2, BRD3 | BRD4 5/4885BRD2 2/4885BRD3 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.