SCHEMBL22866501

SCHEMBL22866501

Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(C(F)(F)F)c(N4CCN(C)CC4)c(C#N)c3c2=O)c2scc(C(=O)OC(C)(C)C)c2n1

nearest known ligand 0.89

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
▸ EIF4EBP1 Q13541 20/20 0.89

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29559903 1.00 EIF4EBP1 (0.89) EIF4EBP1
SCHEMBL29650582 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866507 0.93 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL22866504 0.90 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL29468116 0.90 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL22866598 0.89 EIF4EBP1 (0.86) EIF4EBP1
SCHEMBL29650445 0.88 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650532 0.88 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650629 0.87 EIF4EBP1 (1.00) EIF4EBP1
SCHEMBL29650559 0.87 EIF4EBP1 (1.00) EIF4EBP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021003157-A1 EIF4E-INHIBITING 4-OXO-3,4-DIHYDROPYRIDO[3,4-D]PYRIMIDINE COMPOUNDS EFFECTOR THERAPEUTICS, INC. (US) 2021-01-07 — — WO disclosed
Send feedback