Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTNNB1 | P35222 | 5/20 | 0.66 |
| ▸ | WNT3A | P56704 | 5/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | PARP1 | P09874 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30089541 | 0.88 | CTNNB1 (0.70) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL29062364 | 0.88 | CTNNB1 (0.70) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL1398937 | 0.86 | CTNNB1 (0.56) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL27612776 | 0.85 | CTNNB1 (0.60) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL3949461 | 0.85 | CTNNB1 (0.60) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL22868038 | 0.84 | CTNNB1 (0.48) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL11632592 | 0.83 | CTNNB1 (0.52) | CTNNB1WNT3AKMT2ALMNAMAPT | |
| SCHEMBL315926 | 0.82 | CTNNB1 (0.54) | CTNNB1WNT3AHDAC6KMT2ALMNA | |
| SCHEMBL3588375 | 0.82 | CTNNB1 (0.60) | CTNNB1WNT3AHDAC8HDAC6KMT2A | |
| SCHEMBL30416977 | 0.82 | CTNNB1 (0.60) | CTNNB1WNT3AHDAC8HDAC6KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021003295-A1 | MODULATORS OF HSD17B13 AND METHODS OF USE THEREOF | REGENERON PHARMACEUTICALS, INC. (US) | 2021-01-07 | — | — | WO | disclosed |