Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 10/20 | 0.39 |
| ▸ | EED | O75530 | 9/20 | 0.39 |
| ▸ | RBBP4 | Q09028 | 9/20 | 0.39 |
| ▸ | SUZ12 | Q15022 | 9/20 | 0.39 |
| ▸ | AEBP2 | Q6ZN18 | 9/20 | 0.39 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | HPGDS | O60760 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21342274 | 0.91 | EZH2 (0.39) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL25514539 | 0.90 | RET (0.35) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21342281 | 0.88 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL22872247 | 0.87 | EED (0.35) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL25514525 | 0.82 | CDK5 (0.38) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21341798 | 0.82 | EZH2 (0.64) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL19964704 | 0.81 | EED (0.57) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL21342285 | 0.79 | EZH2 (0.41) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL25514514 | 0.78 | EZH2 (0.43) | EZH2 | |
| SCHEMBL22817667 | 0.77 | CDK5 (0.39) | EZH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3763712-B1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | HAIHE BIOPHARMA CO LTD (CN) | 2021-11-24 | — | — | EP | disclosed |
| EP-3763712-A1 | INDOLIZINE COMPOUNDS, PREPARATION METHOD AND USE THEREOF | Shanghai Haihe Pharmaceutical Co., Ltd. (CN) | 2021-01-13 | — | — | EP | disclosed |