Predicted protein targets (top 2)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.56 |
| ▸ | JAK1 | P23458 | 20/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22878547 | 0.86 | JAK2 (0.56) | JAK2JAK1 | |
| SCHEMBL22878549 | 0.85 | JAK2 (0.58) | JAK2JAK1 | |
| SCHEMBL22878373 | 0.84 | JAK2 (0.57) | JAK2JAK1 | |
| SCHEMBL22878208 | 0.81 | JAK2 (0.57) | JAK2JAK1 | |
| SCHEMBL17284738 | 0.80 | JAK2 (0.47) | JAK2JAK1 | |
| SCHEMBL22878402 | 0.79 | JAK2 (0.55) | JAK2JAK1 | |
| SCHEMBL22878408 | 0.79 | JAK2 (0.56) | JAK2JAK1 | |
| SCHEMBL22878406 | 0.79 | JAK2 (0.55) | JAK2JAK1 | |
| SCHEMBL22878206 | 0.78 | JAK2 (0.58) | JAK2JAK1 | |
| SCHEMBL22878274 | 0.73 | JAK2 (0.54) | JAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3145929-B1 | 5-CHLORO-2-DIFLUOROMETHOXYPHENYL PYRAZOLOPYRIMIDINE COMPOUNDS WHICH ARE JAK INHIBITORS | HOFFMANN LA ROCHE (CH) | 2021-01-13 | — | — | EP | disclosed |