Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 17/20 | 0.74 |
| ▸ | JAK2 | O60674 | 3/20 | 0.47 |
| ▸ | JAK1 | P23458 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29771514 | 0.84 | LRRK2 (0.66) | LRRK2 | |
| SCHEMBL22890267 | 0.84 | LRRK2 (0.66) | LRRK2 | |
| SCHEMBL29740981 | 0.80 | LRRK2 (0.62) | LRRK2JAK2JAK1 | |
| SCHEMBL22889932 | 0.77 | LRRK2 (0.70) | LRRK2 | |
| SCHEMBL22890683 | 0.75 | LRRK2 (0.78) | LRRK2 | |
| SCHEMBL22890307 | 0.74 | LRRK2 (0.71) | LRRK2 | |
| SCHEMBL22445859 | 0.74 | LRRK2 (0.50) | LRRK2 | |
| SCHEMBL29644068 | 0.74 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL22890732 | 0.74 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL22890867 | 0.73 | LRRK2 (0.58) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021007477-A1 | INDAZOLES AND AZAINDAZOLES AS LRRK2 INHIBITORS | E-SCAPE BIO, INC. (US) | 2021-01-14 | — | — | WO | disclosed |