Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SNCA | P37840 | 1/20 | 0.73 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | RAB9A | P51151 | 5/20 | 0.50 |
| ▸ | NPC1 | O15118 | 4/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 4/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 4/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | NR0B1 | P51843 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15436204 | 0.92 | SNCA (0.62) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL17279918 | 0.91 | SNCA (0.82) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL10057827 | 0.88 | SNCA (0.77) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15425097 | 0.85 | SNCA (0.74) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL21440053 | 0.85 | SNCA (0.73) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| Emrusolmin SCHEMBL21440048 | 0.85 | SNCA (1.00) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15425086 | 0.85 | SNCA (0.73) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL16500510 | 0.85 | SNCA (0.73) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15425059 | 0.85 | SNCA (0.73) | SNCAMAPTRAB9ANPC1SMN1; SMN2 | |
| SCHEMBL15425055 | 0.85 | SNCA (0.73) | SNCAMAPTRAB9ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307381-B1 | NEW DRUGS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES | UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) | 2021-01-13 | — | — | EP | disclosed |