Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 4/20 | 0.65 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | MEN1 | O00255 | 5/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | RAB9A | P51151 | 4/20 | 0.48 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.47 |
| ▸ | TP53 | P04637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GLA | P06280 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL560667 | 0.86 | APP (0.73) | APPMAPTALOX15HPGDMEN1 | |
| Bromide SCHEMBL1660202 | 0.85 | APP (0.71) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL15425076 | 0.83 | APP (0.69) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL1659208 | 0.83 | MAPT (0.68) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL16500504 | 0.83 | APP (0.65) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL8002529 | 0.83 | MAPT (0.68) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL31660327 | 0.83 | MAPT (0.68) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL26095496 | 0.83 | MAPT (0.68) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL31659862 | 0.83 | MAPT (0.68) | APPMAPTALOX15HPGDMEN1 | |
| SCHEMBL26096016 | 0.80 | APP (0.60) | APPMAPTALOX15HPGDMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2307381-B1 | NEW DRUGS FOR INHIBITING AGGREGATION OF PROTEINS INVOLVED IN DISEASES LINKED TO PROTEIN AGGREGATION AND/OR NEURODEGENERATIVE DISEASES | UNIV MUENCHEN LUDWIG MAXIMILIANS (DE) | 2021-01-13 | — | — | EP | disclosed |