Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | QPCT | Q16769 | 11/20 | 0.54 |
| ▸ | BRD4 | O60885 | 3/20 | 0.44 |
| ▸ | BRD3 | Q15059 | 3/20 | 0.44 |
| ▸ | BRD2 | P25440 | 2/20 | 0.44 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900224 | 0.95 | QPCT (0.48) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900516 | 0.91 | QPCT (0.52) | QPCTTP53MDM2 | |
| SCHEMBL22900350 | 0.89 | QPCT (0.55) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900208 | 0.88 | QPCT (0.54) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900246 | 0.86 | QPCT (0.52) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900343 | 0.85 | QPCT (0.53) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900524 | 0.85 | QPCT (0.52) | QPCTMDM2 | |
| SCHEMBL22900249 | 0.85 | BRD4 (0.44) | QPCTBRD4BRD3BRD2CREBBP | |
| SCHEMBL22900221 | 0.84 | QPCT (0.53) | QPCT | |
| SCHEMBL22900181 | 0.83 | QPCT (0.52) | QPCTBRD4BRD3BRD2CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009068-A1 | N-SUBSTITUTED-3,4-(FUSED 5-RING)-5-PHENYL-PYRROLIDINE-2-ONE COMPOUNDS AS INHIBITORS OF ISOQC AND/OR QC ENZYME | SCENIC IMMUNOLOGY B.V. (NL) | 2021-01-21 | — | — | WO | disclosed |