Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 14/20 | 0.72 |
| ▸ | CDK2 | P24941 | 14/20 | 0.72 |
| ▸ | CDK1 | P06493 | 12/20 | 0.72 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.72 |
| ▸ | CDK4 | P11802 | 10/20 | 0.60 |
| ▸ | CCND1 | P24385 | 10/20 | 0.60 |
| ▸ | CCND3 | P30281 | 10/20 | 0.60 |
| ▸ | CDK6 | Q00534 | 10/20 | 0.60 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.46 |
| ▸ | CDK7 | P50613 | 5/20 | 0.46 |
| ▸ | CDK9 | P50750 | 5/20 | 0.46 |
| ▸ | CCNH | P51946 | 5/20 | 0.46 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.44 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.44 |
| ▸ | MERTK | Q12866 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.42 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.41 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22900967 | 0.89 | CCNE1 (0.60) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22901207 | 0.86 | CCNE1 (0.59) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900903 | 0.84 | CCNE1 (1.00) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900865 | 0.84 | CCNE1 (0.84) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900840 | 0.83 | CCNE1 (1.00) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900862 | 0.80 | CCNE1 (0.77) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22901199 | 0.80 | CCNE1 (0.79) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900843 | 0.79 | CCNE1 (1.00) | CCNE1CDK2CDK1CCNB1CDK4 | |
| SCHEMBL22900832 | 0.79 | CCNE1 (0.70) | CCNE1CDK2CDK1CCNB1CDK4 | |
| Hydrochloric Acid SCHEMBL30810459 | 0.78 | CCNE1 (0.69) | CCNE1CDK2CDK1CCNB1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210017156-A1 | PYRAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | INCYTE CORPORATION | 2021-01-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210017156-A1 | PYRAZOLYL PYRIMIDINYLAMINE COMPOUNDS AS CDK2 INHIBITORS | CDK2, CDK2AP2, CDK4 | CCNE1 42/4885CDK2 1/4885CDK1 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.