Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 2/20 | 0.42 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | P4HTM | Q9NXG6 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | RAD52 | P43351 | 1/20 | 0.37 |
| ▸ | CDK4 | P11802 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29398215 | 0.80 | PTK2 (0.48) | PTK2AURKAMAPK10MAPK8MAPT | |
| SCHEMBL22191517 | 0.77 | PTK2 (0.46) | PTK2AURKAMAPK10MAPK8MAPT | |
| SCHEMBL3951907 | 0.76 | AURKA (0.56) | PTK2AURKAMAPK10MAPK8MAPT | |
| SCHEMBL22902924 | 0.75 | HDAC6 (0.53) | PTK2AURKAMAPK8MAPTKDM4E | |
| SCHEMBL18434144 | 0.75 | PTK2 (0.44) | PTK2AURKAMAPK10MAPK8MAPT | |
| SCHEMBL18434243 | 0.73 | PTK2 (0.46) | PTK2AURKAMAPK10MAPK8POLB | |
| SCHEMBL22902684 | 0.72 | GRM5 (0.47) | MAPTKDM4EMEN1KMT2AHTT | |
| SCHEMBL17110620 | 0.72 | POLB (0.56) | PTK2AURKAMAPK10MAPK8MAPT | |
| SCHEMBL18433847 | 0.71 | SMN1; SMN2 (0.51) | PTK2MAPK10MAPK8MAPTNPC1 | |
| SCHEMBL28220479 | 0.71 | MEN1 (0.69) | PTK2MAPTMEN1KMT2AHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011428-A1 | HETEROCYCLIC KINASE INHIBITORS | GB005, INC. (US) | 2021-01-21 | — | — | WO | disclosed |