Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22905512 | 0.81 | POLB (0.58) | POLBTSHRSMN1; SMN2NPC1LMNA | |
| SCHEMBL22606339 | 0.75 | POLB (0.41) | POLBTSHRSMN1; SMN2NPC1LMNA | |
| SCHEMBL22905633 | 0.72 | TDP1 (0.58) | POLBTSHRSMN1; SMN2LMNAHPGD | |
| SCHEMBL22905581 | 0.72 | POLB (0.60) | POLBTSHRSMN1; SMN2NPC1LMNA | |
| SCHEMBL10426958 | 0.72 | TDP1 (0.53) | POLBTSHRSMN1; SMN2NPC1MAPK1 | |
| SCHEMBL3135172 | 0.68 | TDP1 (0.53) | POLBTSHRSMN1; SMN2NPC1MAPK1 | |
| SCHEMBL22905411 | 0.68 | HPGD (0.33) | HPGDCA12CA1CA3CA4 | |
| SCHEMBL22905485 | 0.68 | TDP1 (0.38) | CA12CA1CA3CA4CA6 | |
| SCHEMBL2588817 | 0.67 | MAPT (0.52) | POLBTSHRLMNAMAPK1HPGD | |
| SCHEMBL2588819 | 0.67 | MAPT (0.52) | POLBTSHRLMNAMAPK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009566-A1 | N-((1,2,3,5,6,7-HEXAHYDRO-S-INDACEN-4-YL)CARBAMOYL)-4,5,6,7-TETRAHYDROBENZOFURAN -2-SULFONAMIDE DERIVATIVES AND RELATED COMPOUNDS AS NLPR3 MODULATORS FOR THE TREATMENT OF MULTIPLE SCLEROSIS (MS) | ZOMAGEN BIOSCIENCES LTD (US) | 2021-01-21 | — | — | WO | disclosed |