Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.32 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.30 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12112091 | 1.00 | MEN1 (0.40) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL26495735 | 1.00 | MEN1 (0.40) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL21105780 | 0.85 | KDM4E (0.40) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL21105937 | 0.85 | KDM4E (0.40) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL23602083 | 0.85 | KDM4E (0.40) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL22906424 | 0.84 | MEN1 (0.38) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL23696569 | 0.84 | MEN1 (0.38) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL25729107 | 0.84 | MEN1 (0.38) | MEN1KMT2ABLMPMP22HSD17B10 | |
| SCHEMBL23696570 | 0.83 | MEN1 (0.37) | MEN1KMT2AKDM4ETDP1 | |
| SCHEMBL21106845 | 0.83 | KDM4E (0.38) | MEN1KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023192586-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2023-10-05 | — | — | WO | disclosed |
| WO-2022125790-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2022-06-16 | — | — | WO | disclosed |
| WO-2021127278-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021127190-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-06-24 | — | — | WO | disclosed |
| WO-2021011868-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |