SCHEMBL22906709

SCHEMBL22906709

Cn1c2ccncc2c2ccc(-c3ccc(OCCOCCOCCOCCOCCOc4ccc5c(c4)C(=O)N(C4CCC(=O)NC4=O)C5=C4CCC4)nc3C(F)(F)F)cc21

nearest known ligand 0.42

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRD9 Q9H8M2 17/20 0.42
MAPT P10636 3/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29547663 0.93 BRD9 (0.47) BRD9MAPT
SCHEMBL20120271 0.93 BRD9 (0.47) BRD9MAPT
SCHEMBL20233817 0.85 BRD9 (0.39) BRD9MAPT
SCHEMBL20129119 0.85 BRD9 (0.48) BRD9MAPT
SCHEMBL20120510 0.84 BRD9 (0.47) BRD9MAPT
SCHEMBL20120846 0.83 BRD9 (0.49) BRD9MAPT
SCHEMBL29547458 0.83 BRD9 (0.49) BRD9MAPT
SCHEMBL20120317 0.83 BRD9 (0.49) BRD9MAPT
SCHEMBL29857193 0.81 BRD9 (0.49) BRD9MAPT
SCHEMBL27098507 0.81 BRD9 (0.49) BRD9MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2021011913-A1 TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE ARVINAS OPERATIONS, INC. (US) 2021-01-21 WO disclosed