Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | GRM5 | P41594 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27601501 | 0.85 | GRM5 (0.44) | NPC1GRM5TSHRLTA4HEPHX2 | |
| SCHEMBL10390190 | 0.85 | CETP (0.51) | NPC1TSHREPHX2ALDH1A1MAPK1 | |
| SCHEMBL13472200 | 0.85 | NPC1 (0.46) | NPC1GRM5TSHRALDH1A1MAPT | |
| SCHEMBL9956104 | 0.84 | TSHR (0.54) | NPC1GRM5TSHRALDH1A1MAPT | |
| SCHEMBL25215220 | 0.84 | EPHX2 (0.52) | TSHREPHX2MAPTRXFP1L3MBTL1 | |
| SCHEMBL10798829 | 0.84 | CETP (0.54) | NPC1TSHREPHX2ALDH1A1MAPK1 | |
| SCHEMBL31287839 | 0.84 | CETP (0.54) | NPC1TSHREPHX2ALDH1A1MAPK1 | |
| SCHEMBL25240977 | 0.84 | EPHX2 (0.52) | TSHREPHX2MAPTRXFP1L3MBTL1 | |
| SCHEMBL25246359 | 0.84 | EPHX2 (0.52) | TSHREPHX2MAPTRXFP1L3MBTL1 | |
| SCHEMBL8659917 | 0.84 | CETP (0.54) | NPC1TSHREPHX2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021011913-A1 | TAU-PROTEIN TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2021-01-21 | — | — | WO | disclosed |