Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 2/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.67 |
| ▸ | GAA | P10253 | 6/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.67 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.65 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.65 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 6/20 | 0.58 |
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.45 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.45 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4663177 | 0.93 | CD274 (0.64) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL11730124 | 0.93 | CD274 (0.68) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL22908615 | 0.87 | KMT2A (0.63) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL9377730 | 0.84 | KMT2A (0.72) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL22908696 | 0.84 | GAA (0.62) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL19336187 | 0.81 | APP (0.66) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL1562748 | 0.81 | APP (0.91) | APPKMT2AGAATDP1CA12 | |
| SCHEMBL8621001 | 0.81 | KMT2A (0.58) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL22909492 | 0.80 | CD274 (0.64) | APPKMT2AGAATDP1CD274 | |
| SCHEMBL29392433 | 0.80 | CA12 (0.70) | APPKMT2AGAACD274PDCD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009384-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2021-01-21 | — | — | WO | disclosed |
| EP-3766544-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | Centre Hospitalier Regional Universitaire de Lille (FR) | 2021-01-20 | — | — | EP | disclosed |