Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD274 | Q9NZQ7 | 12/20 | 1.00 |
| ▸ | PDCD1 | Q15116 | 10/20 | 1.00 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.56 |
| ▸ | PDE4A | P27815 | 5/20 | 0.56 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.56 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.56 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22908681 | 0.84 | CD274 (1.00) | CD274PDCD1GAAL3MBTL1KDM4E | |
| SCHEMBL15521537 | 0.83 | CD274 (0.76) | CD274PDCD1ALDH1A1GAA | |
| SCHEMBL15058050 | 0.83 | PDE4B (0.79) | CD274PDCD1PDE4BPDE4APDE4C | |
| SCHEMBL22908675 | 0.81 | CD274 (1.00) | CD274PDCD1ALDH1A1GAAHPGD | |
| SCHEMBL22908607 | 0.79 | CD274 (1.00) | CD274PDCD1GAAL3MBTL1KDM4E | |
| SCHEMBL16979677 | 0.79 | CD274 (0.74) | CD274PDCD1ALDH1A1GAAHPGD | |
| SCHEMBL22909491 | 0.79 | CD274 (1.00) | CD274PDCD1ALDH1A1GAAKDM4E | |
| SCHEMBL22908621 | 0.77 | CD274 (1.00) | CD274PDCD1GAAL3MBTL1KDM4E | |
| SCHEMBL15057911 | 0.75 | PDCD1 (0.60) | CD274PDCD1PDE4BPDE4APDE4C | |
| SCHEMBL28265426 | 0.75 | PDE4B (0.60) | CD274PDCD1PDE4BPDE4APDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021009384-A1 | NOVEL PYRAZOLONE DERIVATIVES AS PD-1/PD-L1 INTERACTION INHIBITORS | CENTRE HOSPITALIER REGIONAL UNIVERSITAIRE DE LILLE (FR) | 2021-01-21 | — | — | WO | disclosed |