Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR7 | Q9NYK1 | 19/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | VCP | P55072 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20457646 | 1.00 | TLR7 (0.41) | TLR7MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL22911663 | 0.84 | TLR7 (0.44) | TLR7 | |
| SCHEMBL22281788 | 0.82 | TLR7 (0.43) | TLR7MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL22911645 | 0.82 | TLR7 (0.41) | TLR7MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL21083413 | 0.82 | TLR7 (0.41) | TLR7MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL22911662 | 0.79 | TLR7 (0.39) | TLR7MEN1ALDH1A1LMNACYP3A4 | |
| SCHEMBL6983803 | 0.74 | TLR7 (0.46) | TLR7 | |
| SCHEMBL22911737 | 0.71 | TLR7 (0.46) | TLR7 | |
| SCHEMBL22911735 | 0.70 | TLR7 (0.53) | TLR7 | |
| SCHEMBL8440057 | 0.69 | TLR7 (0.50) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3230298-B1 | 3-SUBSTITUTED 5-AMINO-6H-THIAZOLO[4,5-D]PYRIMIDINE-2,7-DIONE COMPOUNDS FOR THE TREATMENT AND PROPHYLAXIS OF VIRUS INFECTION | HOFFMANN LA ROCHE (CH) | 2021-01-20 | — | — | EP | disclosed |