Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | DDT | P30046 | 2/20 | 0.48 |
| ▸ | APP | P05067 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 4/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 4/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22914919 | 0.89 | DDT (0.50) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL29709845 | 0.89 | DDT (0.50) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL22914933 | 0.82 | APP (0.43) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL22914921 | 0.81 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL29709874 | 0.81 | MAPT (0.51) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL29709841 | 0.79 | DDT (0.53) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL22914936 | 0.79 | DDT (0.53) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL22914923 | 0.78 | MAPT (0.47) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL22914925 | 0.78 | DDT (0.49) | NPC1RAB9ASMN1; SMN2KMT2ADDT | |
| SCHEMBL29709834 | 0.78 | MAPT (0.47) | NPC1RAB9ASMN1; SMN2KMT2ADDT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |