Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | DDT | P30046 | 1/20 | 0.46 |
| ▸ | MIF | P14174 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | NPY1R | P25929 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | NPY2R | P49146 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.44 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29709818 | 0.89 | MAPT (0.51) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914926 | 0.89 | MAPT (0.51) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914922 | 0.87 | MAPT (0.50) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL29709874 | 0.87 | MAPT (0.51) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914921 | 0.87 | MAPT (0.51) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL29709912 | 0.85 | MAPT (0.47) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914928 | 0.85 | MAPT (0.47) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL29709841 | 0.85 | DDT (0.53) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914936 | 0.85 | DDT (0.53) | MAPTDDTMIFLMNAALDH1A1 | |
| SCHEMBL22914919 | 0.84 | DDT (0.50) | MAPTDDTMIFLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021016594-A1 | SECOND GENERATION INHIBITORS OF MITOCHONDRIAL PERMEABILITY TRANSITION PORE WITH IMPROVED PLASMA STABILITY | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2021-01-28 | — | — | WO | disclosed |