Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.55 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.55 |
| ▸ | APAF1 | O14727 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.55 |
| ▸ | NAAA | Q02083 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RAD52 | P43351 | 2/20 | 0.41 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | DGKA | P23743 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL2293049 | 0.99 | MEN1 (0.53) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL2782994 | 0.97 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| Bromide SCHEMBL2296143 | 0.94 | MEN1 (0.50) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL2288341 | 0.93 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL786109 | 0.88 | RECQL (0.47) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| Bromide SCHEMBL2291104 | 0.88 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| Bromide SCHEMBL2293071 | 0.88 | MEN1 (0.47) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL2296163 | 0.87 | RECQL (0.46) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL12038001 | 0.87 | SMN1; SMN2 (0.44) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 | |
| SCHEMBL18203213 | 0.86 | MEN1 (0.44) | MEN1KMT2ASMN1; SMN2NPSR1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2183220-B1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | UNIV DUBLIN CITY (IE) | 2016-11-09 | — | — | EP | disclosed |
| US-8541598-B2 | Biodegradable solvents for the chemical industry | DUBLIN CITY UNIVERSITY (IE) | 2013-09-24 | — | — | US | disclosed |
| US-20110201824-A1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | DUBLIN CITY UNIVERSITY (IE) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201824-A1 | BIODEGRADABLE SOLVENTS FOR THE CHEMICAL INDUSTRY | TIMM9, B2M, TIMM44 | MEN1 3355/4885KMT2A 3862/4885SMN1; SMN2 1425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.