Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 1/20 | 0.51 |
| ▸ | CCND1 | P24385 | 1/20 | 0.51 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.44 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.44 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.44 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.44 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | CES2 | O00748 | 1/20 | 0.43 |
| ▸ | CES1 | P23141 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10795881 | 0.90 | HDAC4 (0.54) | CDK4CCND1HDAC4HDAC3HDAC1 | |
| SCHEMBL17914174 | 0.85 | CDK4 (0.51) | CDK4CCND1HDAC4HDAC3HDAC1 | |
| SCHEMBL6034132 | 0.85 | CDK4 (0.51) | CDK4CCND1HDAC4HDAC3HDAC1 | |
| SCHEMBL23116831 | 0.83 | ESRRG (0.56) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL11748046 | 0.83 | CDK4 (0.50) | CDK4CCND1HDAC4HDAC3HDAC1 | |
| SCHEMBL23470992 | 0.83 | HDAC4 (0.49) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL28513523 | 0.82 | CDK4 (0.49) | CDK4CCND1HDAC4HDAC3HDAC1 | |
| SCHEMBL23471014 | 0.81 | HDAC4 (0.48) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL12459914 | 0.81 | HDAC4 (0.48) | HDAC4HDAC3HDAC1HDAC7HDAC2 | |
| SCHEMBL23146101 | 0.81 | HDAC4 (0.48) | CDK4CCND1HDAC4HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022253311-A1 | HPK1 INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-12-08 | — | — | WO | disclosed |
| WO-2022253311-A1 | HPK1 INHIBITOR AND USE THEREOF | 武汉人福创新药物研发中心有限公司 | 2022-12-08 | — | — | WO | disclosed |
| CN-115433184-A | HPK1 inhibitor and application thereof | 武汉人福创新药物研发中心有限公司 | 2022-12-06 | — | — | CN | disclosed |
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |