Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.54 |
| ▸ | MTOR | P42345 | 3/20 | 0.34 |
| ▸ | JAK2 | O60674 | 5/20 | 0.34 |
| ▸ | JAK1 | P23458 | 5/20 | 0.34 |
| ▸ | TYK2 | P29597 | 5/20 | 0.34 |
| ▸ | JAK3 | P52333 | 5/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.31 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.31 |
| ▸ | FASN | P49327 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22922560 | 1.00 | MAP4K1 (0.54) | MAP4K1MTORJAK2JAK1TYK2 | |
| SCHEMBL29868936 | 1.00 | MAP4K1 (0.54) | MAP4K1MTORJAK2JAK1TYK2 | |
| SCHEMBL29869147 | 1.00 | MAP4K1 (0.54) | MAP4K1MTORJAK2JAK1TYK2 | |
| SCHEMBL29869239 | 0.94 | MAP4K1 (0.61) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922395 | 0.94 | MAP4K1 (0.61) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29869467 | 0.94 | MAP4K1 (0.61) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922396 | 0.94 | MAP4K1 (0.61) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922390 | 0.88 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL22922389 | 0.88 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 | |
| SCHEMBL29869139 | 0.88 | MAP4K1 (0.67) | MAP4K1JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021013083-A1 | TRICYCLIC COMPOUNDS AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2021-01-28 | — | — | WO | disclosed |