Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FASN | P49327 | 4/20 | 0.58 |
| ▸ | DYRK2 | Q92630 | 10/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | USP7 | Q93009 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17389766 | 0.87 | FASN (0.76) | FASNDYRK2CRBNJAK2USP7 | |
| SCHEMBL17389702 | 0.84 | FASN (0.80) | FASNDYRK2CRBNJAK2USP7 | |
| SCHEMBL17389968 | 0.79 | FASN (0.63) | FASNDYRK2CRBN | |
| SCHEMBL17390091 | 0.77 | FASN (0.71) | FASNDYRK2CRBNJAK2 | |
| SCHEMBL17389973 | 0.77 | FASN (0.92) | FASNDYRK2CRBN | |
| SCHEMBL17389982 | 0.76 | FASN (0.67) | FASNDYRK2CRBN | |
| SCHEMBL16149749 | 0.74 | FASN (1.00) | FASNCRBN | |
| SCHEMBL22926432 | 0.72 | FASN (0.58) | FASN | |
| SCHEMBL21231558 | 0.70 | FASN (0.48) | FASN | |
| SCHEMBL17389875 | 0.70 | FASN (0.82) | FASNDYRK2CRBNJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |