Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.50 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | CHKA | P35790 | 1/20 | 0.48 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3153203 | 0.90 | SMN1; SMN2 (0.57) | POLBSMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL16151078 | 0.87 | SMN1; SMN2 (0.47) | POLBSMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL16156045 | 0.84 | CRBN (0.52) | POLBSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL17389617 | 0.84 | FASN (0.66) | — | |
| SCHEMBL17390054 | 0.83 | FASN (0.52) | POLBSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL12431599 | 0.82 | SMN1; SMN2 (0.70) | POLBSMN1; SMN2HPGDKDM4EALDH1A1 | |
| SCHEMBL15288622 | 0.82 | MKNK1 (0.67) | — | |
| SCHEMBL17389941 | 0.82 | FASN (0.61) | — | |
| SCHEMBL17389761 | 0.81 | FASN (0.55) | POLBSMN1; SMN2KDM4EALDH1A1MAPT | |
| SCHEMBL17389748 | 0.81 | FASN (0.49) | POLBSMN1; SMN2HPGDKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3587406-B1 | 2-HYDROXY-1-{4-[(4-PHENYLPHENYL)CARBONYL]PIPERAZIN-1-YL}ETHAN-1-ONE DERIVATIVES AND RELATED COMPOUNDS AS FATTY ACID SYNTHASE (FASN) INHIBITORS FOR THE TREATMENT OF CANCER | FORMA THERAPEUTICS INC (US) | 2021-01-27 | — | — | EP | disclosed |