Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.45 |
| ▸ | TNF | P01375 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.39 |
| ▸ | GSK3B | P49841 | 1/20 | 0.39 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29434770 | 1.00 | TSHR (0.48) | TSHRGRM4TNFSLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL29908241 | 0.98 | TSHR (0.46) | TSHRGRM4TNFSLC6A2SLC6A4 | |
| SCHEMBL1528610 | 0.86 | CNR1 (0.44) | — | |
| SCHEMBL1528612 | 0.86 | CNR1 (0.44) | — | |
| Hydrochloric Acid SCHEMBL1500635 | 0.84 | CNR1 (0.43) | — | |
| Hydrochloric Acid SCHEMBL1500633 | 0.84 | CNR1 (0.43) | — | |
| SCHEMBL2939744 | 0.82 | GRM4 (0.44) | TSHRGRM4TNFSLC6A2SLC6A4 | |
| SCHEMBL2982599 | 0.82 | TSHR (0.54) | TSHR | |
| SCHEMBL17196263 | 0.81 | KDM4E (0.40) | TSHRGRM4TNFSLC6A2SLC6A4 | |
| SCHEMBL2324270 | 0.81 | DPP4 (0.38) | GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174290-A | Modulators of TREX1 | 星座制药公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021016317-A1 | MODULATORS OF TREX1 | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2021-01-28 | — | — | WO | disclosed |