Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | S1PR3 | Q99500 | 2/20 | 0.76 |
| ▸ | S1PR1 | P21453 | 15/20 | 0.62 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.62 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.62 |
| ▸ | SGPL1 | O95470 | 7/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4159967 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL4159965 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL4176098 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL10299886 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL4173837 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL10078592 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL4173831 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL10078494 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL10078493 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 | |
| SCHEMBL10299885 | 1.00 | S1PR3 (0.76) | S1PR3S1PR1S1PR4S1PR5SGPL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9682078-B2 | Compositions and methods for tissue engineering and cell based therapies | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2017-06-20 | — | — | US | disclosed |
| US-8329676-B2 | Cycloalkane-containing sphingosine 1-phosphate agonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-12-11 | — | — | US | disclosed |
| WO-2012129073-A2 | COMPOSITIONS AND METHODS FOR TISSUE ENGINEERING AND CELL BASED THERAPIES | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2012-09-27 | — | — | WO | disclosed |
| US-8008286-B2 | Method for treatment of neuropathic pain | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2011-08-30 | — | — | US | disclosed |
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2010-09-30 | — | — | US | disclosed |
| US-7754703-B2 | Cycloalkane-containing sphingosine 1-phosphate agonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2010-07-13 | — | — | US | disclosed |
| EP-2203409-A2 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | University Of Virginia Patent Foundation (US) | 2010-07-07 | — | — | EP | disclosed |
| WO-2009043013-A2 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2009-04-02 | — | — | WO | disclosed |
| US-20090062238-A1 | METHOD FOR TREATMENT OF NEUROPATHIC PAIN | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2009-03-05 | — | — | US | disclosed |
| US-20080249070-A1 | Cycloalkane-Containing Sphingosine 1-Phospate Agonists | UNIVERSITY OF VIRGINIA PATENT FOUNDATION | 2008-10-09 | — | — | US | disclosed |
| EP-1863463-A1 | SPHINGOSINE 1-PHOSPHATE AGONISTS COMPRISING CYCLOALKANES AND 5-MEMBERED HETEROCYCLES SUBSTITUED BY AMINO AND PHENYL GROUPS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-12-12 | — | — | EP | disclosed |
| WO-2007089715-A2 | METHOD FOR TREATMENT OF NEUROPATHIC PAIN | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2007-08-09 | — | — | WO | disclosed |
| WO-2006088944-A1 | SPHINGOSINE 1- PHOS PHATE AGONISTS COMPRISING CYCLOALKANES AND 5 -MEMBERED HETEROCYCLES SUBSTITUTED BY AMINO AND PHENYL GROUPS | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090062238-A1 | METHOD FOR TREATMENT OF NEUROPATHIC PAIN | S1PR2, S1PR1, S1PR4 | S1PR3 5/4885S1PR1 2/4885S1PR4 3/4885 |
| US-20080249070-A1 | Cycloalkane-Containing Sphingosine 1-Phospate Agonists | S1PR1, S1PR3, S1PR4 | S1PR3 2/4885S1PR1 1/4885S1PR4 3/4885 |
| US-20100249074-A1 | BENZYL-CYCLOALKYL SPHINGOSINE 1-PHOSPHATE RECEPTOR MODULATORS | S1PR1, S1PR3, S1PR4 | S1PR3 2/4885S1PR1 1/4885S1PR4 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.