SCHEMBL22928985

SCHEMBL22928985

Nc1ncnc2c1ncn2[C@@H]1O[C@@H]2COP(=O)(S)OC3[C@@H](COP(=O)(S)OC1C2O)O[C@@H](n1cnc2c(N)ncnc21)[C@H]3O

nearest known ligand 0.89

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
▸ STING1 Q86WV6 16/20 0.89
▸ LMNA P02545 2/20 0.75
▸ RAPGEF3 O95398 2/20 0.75
▸ GMNN O75496 1/20 0.75
▸ BLM P54132 1/20 0.75
▸ KMT2A Q03164 1/20 0.75
▸ NPSR1 Q6W5P4 1/20 0.75
▸ RAPGEF4 Q8WZA2 1/20 0.75
▸ RXFP1 Q9HBX9 1/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22901660 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL22930771 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL22901661 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL21118752 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL23895049 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL23635844 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL24722613 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL25098577 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL20822086 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM
SCHEMBL21886761 1.00 STING1 (0.89) STING1LMNARAPGEF3GMNNBLM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023004440-A2 STING AGONIST COMBINATION TREATMENTS WITH CYTOKINES IMMUNESENSOR THERAPEUTICS, INC. (US) 2023-01-26 — — WO disclosed
WO-2021016204-A1 ANTIBODY-STING AGONIST CONJUGATES AND THEIR USE IN IMMUNOTHERAPY IMMUNESENSOR THERAPEUTICS, INC. (US) 2021-01-28 — — WO disclosed
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