Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 13/20 | 0.82 |
| ▸ | DDB1 | Q16531 | 5/20 | 0.69 |
| ▸ | IP6K1 | Q92551 | 1/20 | 0.47 |
| ▸ | IP6K3 | Q96PC2 | 1/20 | 0.47 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.47 |
| ▸ | GABRD | O14764 | 1/20 | 0.45 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.45 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.45 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21484152 | 0.90 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL22931974 | 0.87 | CRBN (0.78) | CRBNDDB1IP6K1IP6K3IP6K2 | |
| SCHEMBL6622228 | 0.84 | CRBN (0.70) | CRBNDDB1 | |
| SCHEMBL21496505 | 0.83 | CRBN (0.68) | CRBNDDB1IP6K1GABRDGABRA1 | |
| SCHEMBL21484135 | 0.82 | CRBN (1.00) | CRBNDDB1GABRDGABRA1GABRB1 | |
| SCHEMBL23067572 | 0.82 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL22931976 | 0.81 | CRBN (0.73) | CRBNDDB1 | |
| SCHEMBL2897645 | 0.78 | CRBN (0.65) | CRBNDDB1 | |
| SCHEMBL31722612 | 0.75 | CRBN (0.75) | CRBNDDB1 | |
| SCHEMBL21484126 | 0.75 | CRBN (1.00) | CRBNDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11584748-B2 | Spirocyclic compounds | C4 THERAPEUTICS, INC. (US) | 2023-02-21 | — | — | US | disclosed |
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210032245-A1 | SPIROCYCLIC COMPOUNDS | CRBN, RBX1, XIAP | CRBN 1/4885DDB1 143/4885IP6K1 2074/4885 |
| US-11584748-B2 | Spirocyclic compounds | CRBN, RBX1, XIAP | CRBN 1/4885DDB1 143/4885IP6K1 2074/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.