Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 7/20 | 0.49 |
| ▸ | JAK2 | O60674 | 5/20 | 0.49 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 2/20 | 0.45 |
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.45 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | STAT6 | P42226 | 1/20 | 0.43 |
| ▸ | WEE1 | P30291 | 1/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | INSR | P06213 | 1/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22932113 | 0.82 | BRD4 (0.51) | TTKBRD4JAK2PTK2WEE1 | |
| SCHEMBL13756828 | 0.75 | TTK (0.53) | TTKBRD4JAK2EGFRMAP4K1 | |
| SCHEMBL24464383 | 0.75 | BRD4 (0.46) | TTKBRD4JAK2EGFRCSF1R | |
| SCHEMBL22931705 | 0.75 | BRD4 (0.49) | BRD4JAK2PTK2WEE1FLT3 | |
| SCHEMBL22932102 | 0.74 | JAK2 (0.49) | TTKBRD4JAK2EGFRCSF1R | |
| SCHEMBL22931673 | 0.72 | BRD4 (0.51) | TTKBRD4JAK2EGFRCSF1R | |
| SCHEMBL24687839 | 0.72 | EGFR (0.66) | EGFR | |
| SCHEMBL22931677 | 0.70 | BRD4 (0.66) | BRD4JAK2WEE1FLT3 | |
| SCHEMBL24464360 | 0.69 | BRD4 (0.54) | BRD4JAK2WEE1FLT3 | |
| SCHEMBL264720 | 0.68 | BRD4 (0.73) | BRD4JAK2WEE1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021017384-A1 | DIHYDRO-PYRROLO-PYRIMIDINE SELECTIVE JAK2 INHIBITOR | 上海勋和医药科技有限公司 | 2021-02-04 | — | — | WO | disclosed |