Sugi Predict

Sugi Predict / Compounds / SCHEMBL2293263

SCHEMBL2293263

SCHEMBL2293263

N[C@H]1CCCC(F)(F)[C@@H]1NC(=O)c1nc(-c2cnn3cc(I)ccc23)c(Cl)s1

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MARK3 P27448 8/20 0.56
▸ IRAK4 Q9NWZ3 13/20 0.51
▸ SGK1 O00141 1/20 0.51
▸ CHEK1 O14757 1/20 0.51
▸ IKBKB O14920 1/20 0.51
▸ MAPK13 O15264 1/20 0.51
▸ PDPK1 O15530 1/20 0.51
▸ NUAK1 O60285 1/20 0.51
▸ CCNT1 O60563 1/20 0.51
▸ JAK2 O60674 1/20 0.51
▸ ROCK2 O75116 1/20 0.51
▸ CHEK2 O96017 1/20 0.51
▸ ABL1 P00519 1/20 0.51
▸ RAF1 P04049 1/20 0.51
▸ NTRK1 P04629 1/20 0.51
▸ LCK P06239 1/20 0.51
▸ CSF1R P07333 1/20 0.51
▸ MET P08581 1/20 0.51
▸ HCK P08631 1/20 0.51
▸ PIM1 P11309 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12417983 0.91 MARK3 (0.57) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2295484 0.91 MARK3 (0.57) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2292506 0.90 MARK3 (0.56) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2292685 0.90 MARK3 (0.56) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2292530 0.89 MARK3 (0.55) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL12379357 0.89 MARK3 (0.55) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2293409 0.88 MARK3 (0.54) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2288856 0.88 MARK3 (0.54) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2293346 0.87 MARK3 (0.67) MARK3IRAK4SGK1CHEK1IKBKB
SCHEMBL2296448 0.87 MARK3 (0.67) MARK3IRAK4SGK1CHEK1IKBKB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US claimed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP claimed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US claimed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP disclosed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MARK3, MARK4, MARK1 MARK3 1/4885IRAK4 975/4885SGK1 333/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.