Sugi Predict

Sugi Predict / Compounds / SCHEMBL2293443

SCHEMBL2293443

SCHEMBL2293443

Cc1sc(C(=O)N[C@@H]2[C@H](N)CCCC2(F)F)nc1-c1cnn2cc(-c3cnn(C)c3)ccc12

nearest known ligand 0.51

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ MARK3 P27448 13/20 0.51
▸ GSK3B P49841 4/20 0.51
▸ DYRK1A Q13627 4/20 0.51
▸ IRAK1 P51617 3/20 0.51
▸ SGK1 O00141 2/20 0.51
▸ CHEK1 O14757 2/20 0.51
▸ MAPK13 O15264 2/20 0.51
▸ PDPK1 O15530 2/20 0.51
▸ NUAK1 O60285 2/20 0.51
▸ CCNT1 O60563 2/20 0.51
▸ JAK2 O60674 2/20 0.51
▸ ROCK2 O75116 2/20 0.51
▸ CHEK2 O96017 2/20 0.51
▸ ABL1 P00519 2/20 0.51
▸ RAF1 P04049 2/20 0.51
▸ NTRK1 P04629 2/20 0.51
▸ LCK P06239 2/20 0.51
▸ CSF1R P07333 2/20 0.51
▸ MET P08581 2/20 0.51
▸ HCK P08631 2/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12419196 0.89 MARK3 (0.53) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2291268 0.89 MARK3 (0.53) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2287818 0.88 MARK3 (0.60) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2293509 0.88 MARK3 (0.53) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL12379611 0.86 MARK3 (0.59) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2288772 0.86 MARK3 (0.59) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2288775 0.86 MARK3 (0.59) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2288768 0.86 MARK3 (0.59) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL15104015 0.85 MARK3 (0.58) MARK3GSK3BDYRK1AIRAK1SGK1
SCHEMBL2288840 0.85 MARK3 (0.58) MARK3GSK3BDYRK1AIRAK1SGK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US claimed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP claimed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US claimed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
US-8518911-B2 Pyrazolo[1,5-a]pyridines as MARK inhibitors MERCK SHARP & DOHME CORP. (US) 2013-08-27 — — US disclosed
EP-2320737-B1 PYRAZOLO-[1,5-A]-PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME (US) 2013-07-17 — — EP disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MERCK SHARP & DOHME LLC 2011-08-11 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110195933-A1 PYRAZOLO[1,5-A]PYRIDINES AS MARK INHIBITORS MARK3, MARK4, MARK1 MARK3 1/4885GSK3B 90/4885DYRK1A 348/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.