Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 19/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.52 |
| ▸ | HPGDS | O60760 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 3/20 | 0.49 |
| ▸ | TEC | P42680 | 3/20 | 0.49 |
| ▸ | TXK | P42681 | 2/20 | 0.49 |
| ▸ | BMX | P51813 | 2/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | LCK | P06239 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | FGR | P09769 | 1/20 | 0.49 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FRK | P42685 | 1/20 | 0.49 |
| ▸ | BLK | P51451 | 1/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | ITK | Q08881 | 1/20 | 0.49 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29795718 | 1.00 | BTK (0.52) | BTKCRBNHPGDSEGFRTEC | |
| SCHEMBL29795859 | 0.94 | BTK (0.53) | BTKCRBNHPGDSEGFRTEC | |
| SCHEMBL22940298 | 0.94 | BTK (0.53) | BTKCRBNHPGDSEGFRTEC | |
| SCHEMBL29795784 | 0.93 | BTK (0.51) | BTKCRBNEGFRTECTXK | |
| SCHEMBL22940897 | 0.93 | BTK (0.51) | BTKCRBNEGFRTECTXK | |
| SCHEMBL22940905 | 0.91 | BTK (0.52) | BTKCRBNEGFRTECTXK | |
| SCHEMBL29795969 | 0.91 | BTK (0.52) | BTKCRBNEGFRTECTXK | |
| SCHEMBL22940506 | 0.91 | BTK (0.56) | BTKCRBNHPGDSEGFRTEC | |
| SCHEMBL31194784 | 0.90 | BTK (0.50) | BTKCRBNEGFRTEC | |
| SCHEMBL22940453 | 0.90 | BTK (0.57) | BTKCRBNEGFRTECTXK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021018018-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INIDBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2021-02-04 | — | — | WO | disclosed |