SCHEMBL22943232

SCHEMBL22943232

CN1CCC(CNc2cnnc(Nc3cnc(C#N)cn3)c2)CC1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CHEK1 O14757 20/20 0.61
CHEK2 O96017 4/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22944187 0.85 CHEK1 (0.69) CHEK1CHEK2
SCHEMBL22943209 0.83 CHEK1 (0.65) CHEK1CHEK2
SCHEMBL22944582 0.82 CHEK1 (0.64) CHEK1CHEK2
SCHEMBL22944600 0.82 CHEK1 (0.64) CHEK1CHEK2
SCHEMBL22943220 0.81 CHEK1 (0.68) CHEK1CHEK2
SCHEMBL22943190 0.81 CHEK1 (0.62) CHEK1CHEK2
SCHEMBL22943202 0.81 CHEK1 (0.62) CHEK1CHEK2
SCHEMBL22943372 0.81 CHEK1 (0.62) CHEK1CHEK2
SCHEMBL22944172 0.80 CHEK1 (0.64) CHEK1CHEK2
SCHEMBL22943424 0.80 CHEK1 (0.64) CHEK1CHEK2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-114728949-B Heterocyclic compounds as kinase inhibitors and uses thereof 曙方医药 2024-11-12 CN disclosed
CN-114728949-A Heterocyclic compounds as kinase inhibitors and uses thereof 整体生物科学私人有限公司 2022-07-08 CN disclosed
EP-4007757-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF Integral Biosciences Pvt. Ltd. (IN) 2022-06-08 EP disclosed
WO-2021019514-A1 HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF INTEGRAL BIOSCIENCES PVT. LTD. (IN) 2021-02-04 WO disclosed