Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 20/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | NUAK1 | O60285 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | MARK3 | P27448 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.42 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.42 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.42 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.42 |
| ▸ | RPS6KA1 | Q15418 | 1/20 | 0.42 |
| ▸ | PHKG1 | Q16816 | 1/20 | 0.42 |
| ▸ | MAPK15 | Q8TD08 | 1/20 | 0.42 |
| ▸ | BRSK1 | Q8TDC3 | 1/20 | 0.42 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578238 | 1.00 | CHEK1 (0.47) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL22944209 | 0.90 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL29578206 | 0.90 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL29579435 | 0.89 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL22943402 | 0.89 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL22944636 | 0.89 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL22943432 | 0.89 | CHEK1 (0.48) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL29578953 | 0.88 | CHEK1 (0.46) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL28837306 | 0.88 | CHEK1 (0.46) | CHEK1CHEK2KCNH2NUAK1CDK1 | |
| SCHEMBL22944541 | 0.87 | CHEK1 (0.44) | CHEK1CHEK2KCNH2NUAK1CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728949-A | Heterocyclic compounds as kinase inhibitors and uses thereof | 整体生物科学私人有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021019514-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2021-02-04 | — | — | WO | disclosed |