Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 14/20 | 0.52 |
| ▸ | CHEK2 | O96017 | 4/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29578217 | 1.00 | CHEK1 (0.52) | CHEK1CHEK2GPR119RETPIK3CA | |
| SCHEMBL22944220 | 0.87 | CHEK1 (0.52) | CHEK1CHEK2GPR119 | |
| SCHEMBL29578749 | 0.86 | CHEK1 (0.51) | CHEK1CHEK2GPR119 | |
| SCHEMBL29578213 | 0.86 | CHEK1 (0.53) | CHEK1CHEK2GPR119PIK3CAPRKDC | |
| SCHEMBL29578160 | 0.86 | CHEK1 (0.51) | CHEK1CHEK2GPR119 | |
| SCHEMBL22943273 | 0.86 | CHEK1 (0.53) | CHEK1CHEK2GPR119PIK3CAPRKDC | |
| SCHEMBL22944161 | 0.86 | CHEK1 (0.51) | CHEK1CHEK2GPR119 | |
| SCHEMBL28837296 | 0.85 | CHEK1 (0.50) | CHEK1CHEK2GPR119 | |
| SCHEMBL29578225 | 0.85 | CHEK1 (0.50) | CHEK1CHEK2GPR119 | |
| SCHEMBL22943442 | 0.85 | CHEK1 (0.56) | CHEK1CHEK2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114728949-A | Heterocyclic compounds as kinase inhibitors and uses thereof | 整体生物科学私人有限公司 | 2022-07-08 | — | — | CN | disclosed |
| WO-2021019514-A1 | HETEROCYCLIC COMPOUNDS AS KINASE INHIBITOR AND USES THEREOF | INTEGRAL BIOSCIENCES PVT. LTD. (IN) | 2021-02-04 | — | — | WO | disclosed |