Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBLB | Q13191 | 10/20 | 0.36 |
| ▸ | CBL | P22681 | 3/20 | 0.34 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | PIM1 | P11309 | 3/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | IDH2 | P48735 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29626786 | 0.87 | CBLB (0.48) | CBLB | |
| SCHEMBL22944908 | 0.87 | CBLB (0.48) | CBLB | |
| SCHEMBL28741849 | 0.87 | CBLB (0.48) | CBLB | |
| SCHEMBL22945293 | 0.82 | CBLB (0.50) | CBLB | |
| SCHEMBL28741904 | 0.82 | CBLB (0.50) | CBLB | |
| SCHEMBL22945305 | 0.82 | CBLB (0.50) | CBLB | |
| SCHEMBL28741850 | 0.82 | CBLB (0.50) | CBLB | |
| SCHEMBL28741852 | 0.82 | CBLB (0.50) | CBLB | |
| SCHEMBL22944655 | 0.81 | PIK3CA (0.35) | CBLBCBLKDM4ETLR7 | |
| SCHEMBL22945300 | 0.79 | CBLB (0.47) | CBLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021021761-A1 | UREA, AMIDE, AND SUBSTITUTED HETEROARYL COMPOUNDS FOR CBL-B INHIBITION | NURIX THERAPEUTICS, INC. (US) | 2021-02-04 | — | — | WO | disclosed |