Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 18/20 | 0.71 |
| ▸ | JAK2 | O60674 | 11/20 | 0.67 |
| ▸ | JAK3 | P52333 | 11/20 | 0.50 |
| ▸ | TYK2 | P29597 | 10/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12424376 | 1.00 | JAK1 (0.71) | JAK1JAK2JAK3TYK2CYP3A4 | |
| SCHEMBL2297954 | 0.83 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL12425715 | 0.83 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2296321 | 0.83 | JAK1 (0.70) | JAK1JAK2 | |
| SCHEMBL12424380 | 0.83 | JAK1 (1.00) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL10281630 | 0.80 | JAK1 (0.73) | JAK1JAK2JAK3TYK2CYP3A4 | |
| SCHEMBL12424568 | 0.80 | JAK1 (1.00) | JAK1JAK2JAK3TYK2CYP3A4 | |
| SCHEMBL2281671 | 0.80 | JAK1 (1.00) | JAK1JAK2JAK3TYK2CYP3A4 | |
| SCHEMBL12385520 | 0.79 | JAK1 (0.60) | JAK1JAK2JAK3TYK2 | |
| SCHEMBL2297918 | 0.79 | JAK1 (0.60) | JAK1JAK2JAK3TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8461328-B2 | Tricyclic heterocyclic compounds, compositions and methods of use thereof | GENENTECH, INC. (US) | 2013-06-11 | — | — | US | disclosed |
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | GENENTECH, INC. (US) | 2011-08-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110201593-A1 | TRICYCLIC HETEROCYCLIC COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF | CCNY, CCNA1, CCNA2 | JAK1 434/4885JAK2 122/4885JAK3 780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.