Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | CHIA | Q9BZP6 | 1/20 | 0.33 |
| ▸ | CPN1 | P15169 | 1/20 | 0.31 |
| ▸ | CPB2 | Q96IY4 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.31 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9059297 | 0.81 | F2 (0.48) | F2CHIACPN1CPB2TMPRSS2 | |
| SCHEMBL9383665 | 0.81 | F2 (0.48) | F2CHIACPN1CPB2TMPRSS2 | |
| SCHEMBL24080956 | 0.76 | PTPN11 (0.31) | PTPN11 | |
| SCHEMBL19735808 | 0.76 | CHRM2 (0.30) | — | |
| SCHEMBL24227043 | 0.73 | F2 (0.50) | F2CHIACPN1CPB2TMPRSS2 | |
| SCHEMBL20618117 | 0.73 | F2 (0.44) | F2CHIATMPRSS2HTR1AADRA2A | |
| SCHEMBL7234914 | 0.73 | F2 (0.71) | F2CHIACPN1CPB2TMPRSS2 | |
| SCHEMBL1276509 | 0.73 | — | — | |
| SCHEMBL584005 | 0.71 | CYP1A2 (0.46) | CYP2D6 | |
| SCHEMBL2270360 | 0.71 | CHRM2 (0.38) | PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3772513-A1 | SHP2 INHIBITORS | C.N.C.C.S. S.c.a.r.l. Collezione Nazionale Dei Composti Chimici e Centro Screening (IT) | 2021-02-10 | — | — | EP | disclosed |