Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 11/20 | 0.59 |
| ▸ | IKZF3 | Q9UKT9 | 3/20 | 0.58 |
| ▸ | DDB1 | Q16531 | 2/20 | 0.58 |
| ▸ | IKZF1 | Q13422 | 2/20 | 0.58 |
| ▸ | BRD4 | O60885 | 2/20 | 0.58 |
| ▸ | TNF | P01375 | 1/20 | 0.58 |
| ▸ | IL1B | P01584 | 1/20 | 0.58 |
| ▸ | MAP1LC3B | Q9GZQ8 | 3/20 | 0.56 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | STAT3 | P40763 | 1/20 | 0.53 |
| ▸ | AXL | P30530 | 5/20 | 0.51 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26147901 | 1.00 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL27925252 | 1.00 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL27944617 | 1.00 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL27925246 | 1.00 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL2382757 | 0.99 | CRBN (0.60) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL22940891 | 0.92 | CRBN (0.59) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL21602681 | 0.92 | CRBN (0.64) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL24142000 | 0.90 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL19747349 | 0.90 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 | |
| SCHEMBL21814682 | 0.90 | CRBN (0.61) | CRBNIKZF3DDB1IKZF1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2021-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210038599-A1 | SMALL MOLECULE DEGRADERS OF POLYBROMO-1 (PBRM1) | PBRM1, SMARCC1, SMARCC2 | CRBN 65/4885IKZF3 282/4885DDB1 395/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.