Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EHMT2 | Q96KQ7 | 7/20 | 0.83 |
| ▸ | SUV39H1 | O43463 | 3/20 | 0.83 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.62 |
| ▸ | EP300 | Q09472 | 2/20 | 0.62 |
| ▸ | NSD2 | O96028 | 1/20 | 0.62 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.62 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.62 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | TACR1 | P25103 | 4/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29623118 | 0.91 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| SCHEMBL29390533 | 0.91 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| SCHEMBL20796090 | 0.91 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| SCHEMBL29779939 | 0.91 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| SCHEMBL18294715 | 0.79 | EHMT2 (0.75) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| Chaetocin SCHEMBL20796284 | 0.77 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| Chaetocin SCHEMBL22065398 | 0.77 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| Chaetocin SCHEMBL19382420 | 0.77 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| Chaetocin SCHEMBL13662584 | 0.77 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 | |
| Chaetocin SCHEMBL13662582 | 0.77 | EHMT2 (1.00) | EHMT2SUV39H1HIF1AEP300NSD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021026395-A1 | COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND METHODS OF THEIR USE IN REVERSING CANCER CHEMORESISTANCE | THE GENERAL HOSPITAL CORPORATION (US) | 2021-02-11 | — | — | WO | disclosed |