Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CD38 | P28907 | 12/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 5/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ATR | Q13535 | 1/20 | 0.40 |
| ▸ | MELK | Q14680 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29725384 | 1.00 | CD38 (0.46) | CD38IRAK4KCNH2ATMATR | |
| SCHEMBL22963961 | 0.86 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL29725441 | 0.86 | IRAK4 (0.48) | IRAK4 | |
| SCHEMBL22964204 | 0.84 | CD38 (0.50) | CD38IRAK4KCNH2ATMATR | |
| SCHEMBL29725408 | 0.84 | CD38 (0.50) | CD38IRAK4KCNH2ATMATR | |
| SCHEMBL22964207 | 0.84 | MELK (0.55) | IRAK4KCNH2ATMATRMELK | |
| SCHEMBL29725386 | 0.84 | MELK (0.55) | IRAK4KCNH2ATMATRMELK | |
| SCHEMBL22964171 | 0.73 | MELK (0.53) | IRAK4MELK | |
| SCHEMBL29725490 | 0.73 | MELK (0.53) | IRAK4MELK | |
| SCHEMBL22964257 | 0.72 | IRAK4 (0.46) | CD38IRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114174279-B | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | claimed |
| CN-114174279-A | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-03-11 | — | — | CN | claimed |
| CN-114174279-B | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
| CN-114174279-A | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2022-03-11 | — | — | CN | disclosed |
| WO-2021026181-A1 | BICYCLIC HETEROCYCLIC COMPOUNDS USEFUL AS IRAK4 INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2021-02-11 | — | — | WO | disclosed |