Sialic Acid

Sialic Acid

SCHEMBL2296552

CC(=O)N[C@H]1[C@H]([C@H](O)[C@H](O)CO)O[C@](O)(C(=O)O)C[C@@H]1O.Nc1ccn([C@@H]2O[C@H](COP(=O)(O)O)[C@@H](O)[C@H]2O)c(=O)n1

nearest known ligand 0.50

Full drug profile on Sugi Atlas →

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ST6GAL1 P15907 11/20 0.50
NANP Q8TBE9 1/20 0.47
TSHR P16473 1/20 0.44
GLA P06280 1/20 0.44
P2RY2 P41231 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Sialic Acid SCHEMBL30081458 1.00 ST6GAL1 (0.50) ST6GAL1NANPTSHRGLAP2RY2
Sialic Acid SCHEMBL30081457 1.00 ST6GAL1 (0.50) ST6GAL1NANPTSHRGLAP2RY2
Sialic Acid SCHEMBL29668373 1.00 ST6GAL1 (0.50) ST6GAL1NANPTSHRGLAP2RY2
Sialic Acid SCHEMBL21068057 1.00 ST6GAL1 (0.50) ST6GAL1NANPTSHRGLAP2RY2
Cytarabine 5'-Phosphate SCHEMBL5094677 0.95 ST6GAL1 (0.50) ST6GAL1TSHRGLAP2RY2
Sialic Acid SCHEMBL28452247 0.94 ST6GAL1 (0.54) ST6GAL1TSHRGLA
Cytarabine 5'-Phosphate SCHEMBL19423351 0.94 ST6GAL1 (0.47) ST6GAL1TSHRGLAP2RY2
Cytarabine 5'-Phosphate SCHEMBL26630601 0.94 ST6GAL1 (0.47) ST6GAL1TSHRGLAP2RY2
Cytarabine 5'-Phosphate SCHEMBL15652697 0.93 ST6GAL1 (0.47) ST6GAL1TSHRGLAP2RY2
Cytarabine 5'-Phosphate SCHEMBL28842430 0.93 ST6GAL1 (0.47) ST6GAL1TSHRGLAP2RY2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 209 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-113975406-A Glycoengineered antibody drug conjugates 建新公司 2022-01-28 CN claimed
US-11160874-B2 Glycoengineered antibody drug conjugates GENZYME CORPORATION (US) 2021-11-02 US claimed
CN-108025083-B Glycoengineered antibody drug conjugates 建新公司 2021-09-03 CN claimed
EP-3204425-B1 GLYCOENGINEERED ANTIBODY DRUG CONJUGATES GENZYME CORP (US) 2020-09-16 EP claimed
US-10064952-B2 Glycoengineered antibody drug conjugates GENZYME CORPORATION (US) 2018-09-04 US claimed
US-9783838-B2 PmST3 enzyme for chemoenzymatic synthesis of alpha-2-3-sialosides THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2017-10-10 US claimed
EP-3204425-A2 GLYCOENGINEERED ANTIBODY DRUG CONJUGATES Genzyme Corporation (US) 2017-08-16 EP claimed
US-20160136299-A1 GLYCOENGINEERED ANTIBODY DRUG CONJUGATES GENZYME CORPORATION 2016-05-19 US claimed
WO-2016057769-A2 GLYCOENGINEERED ANTIBODY DRUG CONJUGATES GENZYME CORPORATION (US) 2016-04-14 WO claimed
CN-101778859-B Improved process for the production of nucleotide sugars NOVO NORDISK AS 2014-03-26 CN claimed
CN-101778859-A Improved process for the production of nucleotide sugars EOSE TECHNOLOGIES INC 2010-07-14 CN claimed
US-20080227172-A1 SIALYLTRANSFERASE AND DNA ENCODING THE SAME SAITO MASAKI 2008-09-18 US claimed
EP-0886640-B1 SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES GLYCOMIMETICS INC (US) 2007-03-21 EP claimed
US-6949372-B2 Engineering intracellular sialylation pathways THE JOHNS HOPKINS UNIVERSITY (US) 2005-09-27 US claimed
US-20030087396-A1 Sialyltransferase and DNA encoding the same SEIKAGAKU CORPORATION (JP) 2003-05-08 US claimed
US-6169077-B1 A SIALYLATED AND FUCOSYLATED CARBOHYDRATE; USE AS ANTIADHESION THERAPEUTICS TREATING INFLAMMATIONS, THEY CAN PREVENT THE SELECTIN RECEPTORS FROM BINDING TO ACTIVATED ENDOTHELIAL CELLS ON THE SURFACE OF LEUCOCYTES GLYCOTECH CORP. 2001-01-02 US claimed
US-5908766-A USING BETA GALACTOSIDE-ALPHA-2,6-SIALYLTRANSFERASE FROM PHOTOBACTERIUM TO EFFICIENTLY ADD SIALIC ACID TO 6 POSITION OF GALACTOSE RESIDUE OF GLYCOCONJUGATE, OR TO SACCHARIDE OR MONOSACCHARIDE WITH 6 POSITION HYDROXY GROUP JAPAN TOBACCO INC. (JP) 1999-06-01 US claimed
EP-0886640-A1 SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES GlycoTech Corp. (US) 1998-12-30 EP claimed
US-5827714-A OBTAINED FROM PHOTOBACTERIUM CULTURE; TRANSFERS SIALIC ACID FROM CYTOSINE-5*-PHOSPHATE-SIALIC ACID TO THE 6-POSITION OF A GALACTOSE RESIDUE IN A SACCHARIDE OR A MONOSACCHARIDE JAPAN TOBACCO INC. (JP) 1998-10-27 US claimed
WO-1997028173-A1 SIALYL-LEWISa AND SIALYL-LEWISx EPITOPE ANALOGUES NOVARTIS AG (CH) 1997-08-07 WO claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11160874-B2 Glycoengineered antibody drug conjugates CD2BP2, B3GAT3, SIGLEC7 ST6GAL1 29/4885NANP 284/4885TSHR 1200/4885
US-20160136299-A1 GLYCOENGINEERED ANTIBODY DRUG CONJUGATES CD2BP2, B3GAT3, SIGLEC7 ST6GAL1 29/4885NANP 284/4885TSHR 1200/4885
US-10064952-B2 Glycoengineered antibody drug conjugates CD2BP2, B3GAT3, SIGLEC7 ST6GAL1 29/4885NANP 284/4885TSHR 1200/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.