Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAE1 | Q13564 | 2/20 | 0.39 |
| ▸ | CA2 | P00918 | 2/20 | 0.39 |
| ▸ | UBA6 | A0AVT1 | 2/20 | 0.39 |
| ▸ | GRK5 | P34947 | 1/20 | 0.39 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.39 |
| ▸ | NEDD8 | Q15843 | 1/20 | 0.39 |
| ▸ | UBA3 | Q8TBC4 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 9/20 | 0.36 |
| ▸ | WDR77 | Q9BQA1 | 9/20 | 0.36 |
| ▸ | ADK | P55263 | 1/20 | 0.34 |
| ▸ | P2RY1 | P47900 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | ACACB | O00763 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL192272 | 0.93 | PRMT5 (0.37) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL10004893 | 0.93 | PRMT5 (0.37) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL10004894 | 0.93 | PRMT5 (0.37) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL192061 | 0.91 | PRMT5 (0.39) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL12988072 | 0.91 | PRMT5 (0.39) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL192062 | 0.91 | PRMT5 (0.39) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL12988075 | 0.91 | PRMT5 (0.39) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL230988 | 0.84 | NAE1 (0.46) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL230987 | 0.84 | NAE1 (0.46) | NAE1CA2UBA6GRK5CSNK1A1 | |
| SCHEMBL192849 | 0.82 | NAE1 (0.49) | NAE1CA2UBA6GRK5CSNK1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2402334-A1 | Inhibitors of E1 Activating Enzymes | Millennium Pharmaceuticals, Inc. (US) | 2012-01-04 | — | — | EP | disclosed |