Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 14/20 | 0.56 |
| ▸ | JAK2 | O60674 | 14/20 | 0.56 |
| ▸ | TYK2 | P29597 | 5/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.44 |
| ▸ | SYK | P43405 | 1/20 | 0.44 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22971276 | 1.00 | JAK1 (0.56) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL22971460 | 1.00 | JAK1 (0.56) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL45724 | 0.83 | JAK1 (0.69) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL25310876 | 0.78 | JAK1 (0.48) | JAK1JAK2TYK2 | |
| SCHEMBL22971079 | 0.77 | JAK2 (0.51) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL22971018 | 0.77 | JAK2 (0.51) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL29611090 | 0.77 | JAK2 (0.51) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL22971277 | 0.77 | JAK2 (0.51) | JAK1JAK2TYK2IKBKBRIPK2 | |
| SCHEMBL22971289 | 0.77 | JAK2 (0.51) | JAK1JAK2TYK2JAK3 | |
| SCHEMBL22971020 | 0.76 | JAK2 (0.50) | JAK1JAK2TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4011880-A1 | JAK KINASE INHIBITOR AND USE THEREOF | Jiangsu Carephar Pharmaceutical Co., Ltd (CN) | 2022-06-15 | — | — | EP | disclosed |
| WO-2021023207-A1 | JAK KINASE INHIBITOR AND USE THEREOF | 江苏柯菲平医药股份有限公司 | 2021-02-11 | — | — | WO | disclosed |