Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 3/20 | 0.54 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | PPARA | Q07869 | 2/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10644936 | 0.91 | HCAR2 (0.53) | HCAR2PTPN1CES2PPARGPPARA | |
| Fumaric Acid SCHEMBL12980929 | 0.87 | HCAR2 (0.69) | HCAR2CES2MEN1THRBHTT | |
| Maleic Acid SCHEMBL12980928 | 0.87 | HCAR2 (0.69) | HCAR2CES2MEN1THRBHTT | |
| (2E)-Hexenoic Acid SCHEMBL25301170 | 0.82 | PTPN1 (0.59) | HCAR2PTPN1KMT2AMAPTPPARG | |
| SCHEMBL9436966 | 0.82 | TSHR (0.46) | HCAR2PTPN1PPARA | |
| SCHEMBL898554 | 0.81 | HCAR2 (0.55) | HCAR2PTPN1CES2MEN1THRB | |
| SCHEMBL11339872 | 0.81 | HCAR2 (0.55) | HCAR2PTPN1CES2MEN1THRB | |
| SCHEMBL23116326 | 0.81 | PTPN1 (0.68) | PTPN1KMT2AMAPTPPARGPPARA | |
| SCHEMBL23116359 | 0.81 | PTPN1 (0.68) | PTPN1KMT2AMAPTPPARGPPARA | |
| SCHEMBL23116356 | 0.81 | PTPN1 (0.68) | PTPN1KMT2AMAPTPPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774777-A2 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |