Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 13/20 | 0.55 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | P2RY12 | Q9H244 | 2/20 | 0.33 |
| ▸ | TOP2A | P11388 | 1/20 | 0.33 |
| ▸ | KDM6B | O15054 | 1/20 | 0.32 |
| ▸ | KDM6A | O15550 | 1/20 | 0.32 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
| ▸ | KDM4B | O94953 | 1/20 | 0.32 |
| ▸ | KDM5C | P41229 | 1/20 | 0.32 |
| ▸ | KDM3B | Q7LBC6 | 1/20 | 0.32 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.32 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.32 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.32 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.32 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.32 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.32 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21458502 | 0.92 | KRAS (0.55) | KRASCRBNP2RY12 | |
| SCHEMBL22973193 | 0.92 | KRAS (0.54) | KRASCRBNP2RY12TOP2AKDM6B | |
| SCHEMBL21458892 | 0.84 | KRAS (0.59) | KRASCRBNP2RY12TOP2A | |
| SCHEMBL30147438 | 0.81 | KRAS (0.70) | KRASCRBNP2RY12 | |
| SCHEMBL21472341 | 0.81 | KRAS (0.66) | KRASCRBN | |
| Hydrochloric Acid SCHEMBL21458938 | 0.81 | KRAS (0.65) | KRASCRBN | |
| SCHEMBL21458678 | 0.80 | KRAS (0.83) | KRASCRBN | |
| SCHEMBL22973106 | 0.80 | KRAS (0.44) | KRASCRBNP2RY12TOP2AKDM6B | |
| SCHEMBL22973189 | 0.77 | KRAS (0.49) | KRASCRBN | |
| SCHEMBL21458454 | 0.76 | KRAS (0.70) | KRASCRBN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3774777-A2 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | Arvinas Operations, Inc. (US) | 2021-02-17 | — | — | EP | disclosed |