Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 6/20 | 0.58 |
| ▸ | CYP1A1 | P04798 | 5/20 | 0.58 |
| ▸ | CYP1B1 | Q16678 | 5/20 | 0.58 |
| ▸ | DCPS | Q96C86 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1395347 | 0.81 | CYP1A1 (0.77) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL29593101 | 0.81 | CYP1A1 (0.77) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| Hydrochloric Acid SCHEMBL29281621 | 0.79 | CYP1A1 (0.77) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL14529287 | 0.78 | CYP1A1 (0.77) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL1084305 | 0.77 | SMN1; SMN2 (0.58) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL14462692 | 0.76 | CYP1A1 (0.49) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL12443214 | 0.76 | CYP1A2 (0.75) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL2296338 | 0.76 | ABCG2 (0.70) | CYP1A2MEN1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL14529164 | 0.75 | CYP1A2 (0.64) | CYP1A2CYP1A1CYP1B1DCPSMEN1 | |
| SCHEMBL5570074 | 0.75 | CYP1A1 (0.55) | CYP1A2CYP1A1CYP1B1DCPSMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140316130-A1 | USE OF MICROFABRICATED DEVICES | HAMMERSMITH IMANET LIMITED (GB) | 2014-10-23 | — | — | US | disclosed |
| EP-2528606-B1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | LEVITZKI ALEXANDER (IL) | 2014-09-24 | — | — | EP | disclosed |
| US-8759363-B2 | Quinazoline-based T cell proliferation inhibitors | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD. (IL) | 2014-06-24 | — | — | US | disclosed |
| US-20130109706-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERSALEM LTD. (IL) | 2013-05-02 | — | — | US | disclosed |
| EP-2528606-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | Yissum Research Development Company of the Hebrew University of Jerusalem Ltd. (IL) | 2012-12-05 | — | — | EP | disclosed |
| WO-2011092695-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | YISSUM RESEARCH DEVELOPMENT COMPANY OF THE HEBREW UNIVERSITY OF JERUSALEM LTD (IL) | 2011-08-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130109706-A1 | QUINAZOLINE-BASED T CELL PROLIFERATION INHIBITORS | IL2, CD4, NFATC1 | CYP1A2 477/4885CYP1A1 1905/4885CYP1B1 2233/4885 |
| US-20140316130-A1 | USE OF MICROFABRICATED DEVICES | MPI, MEN1, TMEM14C | CYP1A2 3230/4885CYP1A1 2218/4885CYP1B1 1143/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.